Activation of the hypothalamic-pituitary-adrenal (HPA) axis (as might occur. for example. when the organism encounters a threat to allostatic balance) leads to the release of cortisol into the bloodstream and. ultimately. https://www.roneverhart.com/Castello-di-Amorosa-Il-Barone-Napa-Valley-Cabernet-Sauvignon-2007/