Chemotherapy was potentiated by E7449 and single agent experienced sizeable antitumor exercise in BRCA-deficient xenografts. In addition, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell lines, probably through TNKS inhibition. In line with this chance, E7449 stabilized axin and TNKS proteins leading to β-catenin de-stabilization and appreciably altered expression of https://momipp46790.getblogs.net/62125300/ml-210-an-overview